Mark T. Curtis, M.D., Ph.D.

Contact Dr. Curtis

132 S. 10th Street
Main Building, Suite 263
Philadelphia, PA 19107

(215) 955-6206

Medical School
M.D., Thomas Jefferson University, 1982

University Appointment
Associate Professor

Other Professional Appointments
Director of Neuropathology

Assistant Director of Autopsy Pathology

Director, Pathology Laser Microdissection Facility

Program Director, Pathology Residency

Research and Clinical Interests
Viral Diseases of the Central Nervous System

Demyelinating Disorders of the Central Nervous System

Publications

Most recent Peer-reviewed Publications

1. Extended normal life after AAVrh10-mediated gene therapy in the mouse model of krabbe disease
2. Accelerated and enhanced effect of CCR5-transduced bone marrow neural stem cells on autoimmune encephalomyelitis
3. CNS recruitment of CD8+ T lymphocytes specific for a peripheral virus infection triggers neuropathogenesis during polymicrobial challenge
4. Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis
5. Lymphocytic choriomeningitis virus-induced mortality in mice is triggered by edema and brain herniation
6. Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis
7. Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophy
8. Revisiting anaplastic astrocytomas I: An expansive growth pattern is associated with a better prognosis
9. Pravastatin in vivo reduces mononuclear cell migration through endothelial monolayers
10. Complex choristoma of the gyrus rectus: A distinct clinicopathologic entity?
11. Biochemical and pathological evaluation of long-lived mice with globoid cell leukodystrophy after bone marrow transplantation
12. AAV-Mediated expression of galactocerebrosidase in brain results in attenuated symptoms and extended life span in murine models of globoid cell leukodystrophy
13. Nerve monitoring and stimulation during endoscopic neck surgery in the pig
14. Generation of transgenic mice expressing insulin-like growth factor-1 under the control of the myelin basic protein promoter: Increased myelination and potential for studies on the effects of increased IGF-1 on experimentally and genetically induced demyelination
15. Silver-haired bat rabies virus variant does not induce apoptosis in the brain of experimentally infected mice
16. Concomitant progressive multifocal leucoencephalopathy and primary central nervous system lymphoma expressing JC virus oncogenic protein, large T antigen
17. Generation of a mouse with low galactocerebrosidase activity by gene targeting: A new model of globoid cell leukodystrophy (Krabbe disease)
18. Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas
19. Utililization of experimental animal model for correlative multispectral MRI and pathological analysis of brain tumors
20. Thoracic neurenteric cyst in an adult: Case report

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