Jonathan R. Brody, PhD
Division Director
Department of Surgery
Division of Surgical Research
Research is at the heart of the mission of the Department of Surgery. Projects in basic science and clinical research have included establishing ECMO capabilities to support critically ill neonates, developing hepatic resection and transplantation techniques, evaluating pancreatic islet-cell xenografting, understanding the molecular aspects of pancreatic, breast, and ovarian cancers, exploring hyperthermia in cancer treatment and examining endothelial-cell, prosthetic-graft interactions.
The diverse interests of Jefferson's faculty allow for a multitude of cross-specialty protocols. The connections between clinically-based faculty and research-based faculty help facilitate a translational and collaborative approach to research.
Clinical Research
- multimodality therapy in pancreatic and colorectal carcinoma
- preoperative chemotherapy in locally advanced breast carcinoma
- incidence and prevention of deep-vein thrombosis
Basic Science Research
- Endothelial-cell and leukocyte migration under conditions of sheer stress
- Skeletal muscle biochemistry and function as it relates to myocardial assistance for failing hearts
- Abnormalities of lipid metabolism during gram-negative septic shock
- Systemic inflammatory response syndrome (SIRS)
- Pathobiology of arterial wall cells associated with various peripheral vascular disease states
- Endogenous mechanisms for regulation of inducible nitric oxide synthase in the pancreatic islets
- Protection of the islets by osteopontin for islet transplantation
- Regulation of osteopontin by cytokines in insulin producing cells
- The role of the pancreatic renin angiotensin system (RAS) in type 1 diabetes
- Osteopontin role in type 1 diabetes
- Understanding the role of mRNA stability in pancreatic cancer cells
- Understanding the role of mRNA stability in the tumor microenvironment
- Trying to optimize current therapies and develop new therapies for the treatment of different cancers (e.g., ovarian and pancreatic)
- Understanding the role of caloric intake in regards to pancreatic cancer development
- Trying to identify novel early detection markers for pancreatic cancer
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