05B4 Xia, Xugang - Jefferson Medical College - Thomas Jefferson University
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Xugang Xia, MD, PhD

Contact Dr. Xia

1020 Locust Street
Jefferson Alumni Hall, Suite 508
Philadelphia, PA 19107

(215) 503-1037

Most Recent Peer-reviewed Publications

  1. Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats
  2. Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats
  3. Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice
  4. Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake
  5. TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice
  6. FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
  7. Transgenic rat model of neurodegeneration caused by mutation in the TDP gene
  8. Nerve injection of viral vectors efficiently transfers transgenes into motor neurons and delivers RNAi therapy against ALS
  9. Developing tTA transgenic rats for inducible and reversible gene expression
  10. A tightly regulated Pol III promoter for synthesis of miRNA genes in tandem
  11. A construct with fluorescent indicators for conditional expression of miRNA
  12. Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression
  13. Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo
  14. Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes
  15. Transgenic RNAi: Accelerating and expanding reverse genetics in mammals
  16. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice
  17. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice.
  18. An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi
  19. Dominant disease gene gets silenced
  20. An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi.
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