Suite 455
Philadelphia, PA 19107
(215) 503-4695
Most Recent Peer-reviewed Publications
- Identification of viral genomic elements responsible for rabies virus neuroinvasiveness
- Development of a cocktail of recombinant-expressed human rabies virus-neutralizing monoclonal antibodies for postexposure prophylaxis of rabies
- Differential expression of growth factors at the cellular level in virus-infected brain
- Silver-haired bat rabies virus variant does not induce apoptosis in the brain of experimentally infected mice
- Effect of rabies virus infection on gene expression in mouse brain
Medical School
BSc, Belorussian State University, Minsk, Belarus - 1975
PhD, Institute of Medical Genetics of the Russian Academy of Medical Sciences, Moscow, Russia
- 1982
Expertise and Research Interests
My research interest is focused on understanding of the genesis and mechanisms of pro-tumor activation of glioma-infiltrated M2 cells for future mechanistic, diagnostic and potentially therapeutic studies. The goal of my studies is to test the hypothesis that glioma progression is associated with the accumulation of cells bearing M2 monocyte/macrophages markers, which are the main sources of mediators for immunomodulation, angiogenesis and tumor progression. Alternative activated and anti-inflammatory M2 cells may be an attractive target for future anti-cancer therapies.
Keywords
Mechanisms of immunosuppression in malignant gliomas