My research is focused on the application of computational biology and bioinformatics in the study of tumorigenesis.  My work is driven by two specific aims: to identify biomarkers of disease onset and progression and to investigate and describe mechanisms of action of diseases and therapeutics from a gene, protein, pathway, and system perspective.

Current Research Projects

• Mechanisms of action of tamoxifen in estrogen receptor positive breast cancer cells
• Protein markers of prognosis in formalin-fixed paraffin embedded breast cancer tissue<
• Optimization of phosphopeptide enrichment from complex samples for mass spectrometry based identification and quantification
• Plasma biomarkers for breast cancer diagnosis
• Next-generation sequencing to identify genetic markers of X-linked mental retardation
• Next-generation sequencing for comparison of transformed cell lines and primary blood samples
• PPAR? acetylation governs protein stability and ligand-induced transactivation and transrepression functions
• Cyclin D1 regulation and androgen receptor signaling in prostate cancer
• Cyclin D1 regulation of miRNA expression and secretion

Future Plans

To investigate the role of fatty acid beta-oxidation on breast cancer progression in the tumor microenvironment