My research has been focusing for the past 20 years on the type 1 insulin-like growth factor receptor (IGF-IR), a growth factor receptor that plays a major role in growth, differentiation and transformation. Antibodies to the IGF-IR are presently in clinical trials. Many pharma companies and biotechs use reagents (plasmids and cell lines) developed in my laboratory, which are a steady source of income for our OTT.

Current Research Projects

• The role of micro RNA 145 in down-regulating the IGF-IR signaling pathway. miR145 targets and down-regulates the IGF-IR and its docking protein, the insulin receptor substrate-1 (IRS-1) and causes a dramatic inhibition of cancer cell growth. The work on miR145 has been done with the collaboration and support of Merck Company.
• The mechanism of v-src transformation, which requires the collaboration of the IGF-IR and IRS-1.

Aging; Biochemistry; Biological Signal Transduction; Biomedical Facility; Biophysics; Cell Biology; Cell Cycle Protein; Cell Differentiation; Cell Growth Regulation; Cell Senescence; Complementary Dna; Developmental Biology; Developmental Neurobiology; Diploidy; Dna Binding Protein; Dna Replication; Epidermal Growth Factor; Ethanol; Fibroblast; Gel Electrophoresis; Gene Expression; Genetic Mapping; Genetic Promoter Element; Genetic Regulation; Genetic Regulatory Element; Genetic Transcription; Genetics; Growth Factor Receptor; Growth Inhibitor; Human Physiology; Immortalized Cell; Insulinlike Growth Factor; Messenger Rna; Microinjection; Mitogen; Molecular Biology; Molecular Cloning; Molecular Genetics; Molecular Site; Northern Blotting; Nuclear Runoff Assay; Nucleic Acid Sequence; Oncogene; Pharmacology; Platelet Derived Growth Factor; Polymerase Chain Reaction; Proliferating Cell Nuclear Antigen; Protein Biosynthesis; Protein Purification; Protein Sequence; Protooncogene; Receptor Binding; Receptor Expression; Simian Virus; Structural Gene; Temperature Sensitive Mutant; Tissue Cell Culture; Transcription Factor; Transfection; Virus Antigen; Wi