2238 Wedegaertner, Philip B. - Jefferson Medical College - Thomas Jefferson University
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Philip B. Wedegaertner, PhD

Contact Dr. Wedegaertner

233 S. 10th St.
839 BLSB
Philadelphia, PA 19107

(215) 503-3137

Most Recent Peer-reviewed Publications

  1. Non-canonical signaling and localizations of heterotrimeric G proteins
  2. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein βγ subunits
  3. An N-terminal polybasic motif of Gα q is required for signaling and influences membrane nanodomain distribution
  4. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF
  5. Differences in Gα12- and Gα13-mediated plasma membrane recruitment of p115-RhoGEF
  6. N-terminal polybasic motifs are required for plasma membrane localization of Gα s and Gα q
  7. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
  8. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated Rho guanine-nucleotide exchange factor
  9. Plasma membrane and nuclear localization of G protein-coupled receptor kinase 6A
  10. Assembly and trafficking of heterotrimeric G proteins
  11. Lipid-protein interactions in GPCR-associated signaling
  12. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth
  13. Loss of association between activated Gα q and Gβγ disrupts receptor-dependent and receptor-independent signaling
  14. Functional consequences of Gα13 mutations that disrupt interaction with p115RhoGEF
  15. Identification of a specific domain responsible for JNK2α2 autophosphorylation
  16. Palmitoylation and plasma membrane targeting of RGS7 are promoted by αo
  17. Characterization of the GRK2 binding site of Gαq
  18. Analysis of G-protein-coupled receptor kinase RGS homology domains
  19. Exocytic pathway-independent plasma membrane targeting of heterotrimeric G proteins
  20. A Predicted Amphipathic Helix Mediates Plasma Membrane Localization of GRK5
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