233 South 10th St.
BLSB 830
Philadelphia, PA 19107
(215) 503-7322
BLSB 830
Philadelphia, PA 19107
(215) 503-7322
Most Recent Peer-reviewed Publications
- Introduction-Notch in development and disease
- Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects
- Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila
- Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function
- In Vivo reconstitution of γ-secretase in Drosophila results in substrate specificity
Medical School
PhD, University of California-Berkeley - 1990
Expertise and Research Interests
Signaling mechanisms in neurogenesis and neurodegeneration; cell biology of Notch receptor trafficking and proteolysis; developmental genetics and human disease modeling in Drosophila.
Keywords
signal transduction; Drosophila; genetics; Notch receptor; developmental biology; neuroscience; neurogenesis; Alzheimer's disease; gamma-secretase; membrane trafficking; proteolysis