05B4 Fernandes-Alnemri, Teresa - Jefferson Medical College - Thomas Jefferson University
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Teresa Fernandes-Alnemri, PhD

Contact Dr. Fernandes-Alnemri

233 S. 10th Street
BLSB 902
Philadelphia, PA 19107

(215) 503-4631

Most Recent Peer-reviewed Publications

  1. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
  2. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
  3. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection
  4. Cutting edge: Mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
  5. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
  6. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
  7. Functional consequences of a germline mutation in the leucine-rich repeat domain of NLRP3 Identified in an atypical autoinflammatory disorder
  8. Anti-inflammatory compounds parthenolide and bay 11-7082 are direct inhibitors of the inflammasome
  9. Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
  10. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
  11. Chapter Thirteen Assembly, Purification, and Assay of the Activity of the ASC Pyroptosome
  12. The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila
  13. Mutations in NALP12 cause hereditary periodic fever syndromes
  14. Pyrin Activates the ASC Pyroptosome in Response to Engagement by Autoinflammatory PSTPIP1 Mutants
  15. The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
  16. Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization
  17. The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity
  18. Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death
  19. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
  20. The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein
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