BLSB Room 826
Philadelphia, PA 19107
(215) 503-4573
(215) 923-2117 fax
Most Recent Peer-reviewed Publications
- Crystal structure of a Ba2+-bound gating ring reveals elementary steps in RCK domain activation
- Improved crystallization of Escherichia coli ATP synthase catalytic complex (F1) by introducing a phosphomimetic mutation in subunit €
- Structure of P22 headful packaging nuclease
- Small terminase couples viral DNA binding to genome-packaging ATPase activity
- Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin α5
Medical School
BS/MS in Biochemistry, University of Bari, Italy - 1995
PhD in Structural Biology, European Molecular Biology Laboratory
- 1999
Fellowship
Human Frontier Science Program Postdoctoral fellow, Scripps Research Institute, 1999-2003
Labsite http://www.cingolanilab.org
Expertise and Research Interests
My laboratory uses X-ray crystallography, combined with biophysical, biochemical and cellular techniques to probe the structure and function of large macromolecular machines. We are interested in a variety of biological problems, which include the mechanisms and regulation of nucleocytoplasmic transport, the delivery of viral DNA into living cells, and the structure and regulation of multi-subunit ATP synthases. Our goal is to use rigorous chemical and physical methodologies to study medically-relevant problems that help decipher the most fundamental mechanisms of life and contribute to improve human health. Visit our lab website (http://www.cingolanilab.org/) for more info.
Keywords
X-ray crystallography; Structural Biology; Nucleocytoplasmic Transport; Dual Specificity Phosphatase; Virus Assembly; Viral Genome Ejection/Packaging; ATP-synthase; Multisubunit ATPases
Languages
English, Italian, French, some Portuguese