2238 Benovic, Jeffrey L. - Jefferson Medical College - Thomas Jefferson University
jlb104

Jeffrey L. Benovic, PhD

Contact Dr. Benovic

233 S 10th Street
Philadelphia, PA 19107

(215) 503-4607
(215) 503-5393 fax

Most Recent Peer-reviewed Publications

  1. β-Arrestins and G protein-coupled receptor trafficking
  2. Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor
  3. G-protein-coupled receptors signal victory
  4. Identification and characterization of distinct c-terminal domains of the human hydroxycarboxylic acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization
  5. G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition
  6. Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in Vivo
  7. G protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression
  8. Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth
  9. Differential expression of arrestins is a predictor of breast cancer progression and survival
  10. Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder
  11. G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4
  12. Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but β-arrestin-independent pathways
  13. Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer
  14. Internalization of the human nicotinic acid receptor GPR109A is regulated by G i, GRK2, and arrestin3
  15. Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity
  16. Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function
  17. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
  18. Deletion of the distal COOH-terminus of the A 2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling
  19. G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα
  20. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking
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