05B4 Alnemri, Emad - Jefferson Medical College - Thomas Jefferson University
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Emad Alnemri, PhD

Contact Dr. Alnemri

233, S. 10th Street
BLSB 904
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Most Recent Peer-reviewed Publications

  1. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
  2. Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis
  3. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
  4. Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
  5. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection
  6. Cutting edge: Mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
  7. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
  8. Sensing cytoplasmic danger signals by the inflammasome
  9. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
  10. Functional consequences of a germline mutation in the leucine-rich repeat domain of NLRP3 Identified in an atypical autoinflammatory disorder
  11. Anti-inflammatory compounds parthenolide and bay 11-7082 are direct inhibitors of the inflammasome
  12. THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death
  13. Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
  14. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
  15. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
  16. Erratum: X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility (Nature Cell Biology (2008) vol. 10 (1447-1455))
  17. Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009
  18. Erratum: X-linked and cellular IAPs modulate the stability of C-rAF kinase and cell motility (Nature Cell Biology (2008) vol. 10 (1447-1455))
  19. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
  20. Chapter Thirteen Assembly, Purification, and Assay of the Activit 0133 y of the ASC Pyroptosome
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